The concept of acid-base homeostasis. The main buffer systems of the blood.
Physiologic mechanisms responsible for the normal acid-base balance: role of the respiratory system; role of kidneys.
Typical forms of disorders of acid-base balance. Metabolic acidosis: causes and symptoms.Metabolic alkalosis: causes and symptoms.
Respiratory acidosis: causes and mechanisms. Respiratory alkalosis: causes and mechanisms.
Primary and compensatory changes in various types acidosis and alkalosis.
Laboratory parameters used in diagnostics of acid-base dysbalance.
Methods of teaching
Discussion the major issues under the supervision of a teacher, discussion pathogenetic schemes.
6.6.6. THE LIST OF LITERATURE:
The basic
1. Litvitsky P.F., Pirozhkov S.V., Tezikov E.B. Concise lectures and tests on pathophysiology E-tekstbook. – ГЭОТАР-Медиа, 2007
Additional
2. Textbook of pathology. Harsh Mohan. Body fluid and circulatory disturbances. 4rd edition, Delhi, 2004.- P 100-102.
3. Textbook of medical physiology. Regulation of acid-base balance. A.C. Guyton, J.E. Hall., 9th edition, 1996.-P. 385-403
Methods of control
Oral questioning, checking pathogenetic schemes, testing
The approximate timing of classes
№ | Steps of the class | Time (min) |
Organizational part. Roll Call, reading the goals and objectives of the class, distribution of demonstration material | ||
Discussion the questions, task № 1,2 | ||
Break | ||
Task № 3 | ||
Test | ||
Summarizing the classroom work, assessment of competencies |
Practical work of students
Task № 1. | Study logic structures of the theme. |
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№ 5. Compensatory mechanisms at acid-base balance (ABB) disorders
(The main buffer systems)
Respiratory acidosis | - the main role belongs to hemoglobin buffer (it fills up bicarbonate buffer of plasma and connects protons) |
Non respiratory acidosis | - the main role belongs to bicarbonate and protein buffer |
Respiratory alkalosis | - the main role belongs to protein buffer which dissociates with releasing Н + ions to plasma. |
Non respiratory alkalosis | - the main role belongs to protein buffer. |