Biochemistry

1.Carnitine transports fatty acyl CoA in

A) Cytoplasm

B) Intermembrane space of mitochondria

C) Mitochondrial Matrix

D) Nuclear membrane

2. All of the following statements are true regarding lipoproteins except?

a) VLDL transport endogenous lipids

b) chylomicrons transports lipids to the tissue

c) Increased blood cholesterol is associated with increased LDL receptors

d) Increased HDL is associated with decreased risky of coronary disease.

3. A person on fat free carbohydrate rich diet continues to grow obese. Which of the following lipoproteins is likely to be elevated in blood?

a) Chylomicrons

b)VLDL

c)HDL

d)LDL

4. Which of the following products of triacylglycerol breakdown and subsequent β-Oxidation may undergo gluconeogenesis?

a) Acetyl CoA

b) Propionyl CoA

c) All ketone bodies

d) Some amino acids

5. Deficiency of biotin results in decrease in

a) Amino acid synthesis

b) Lipid synthesis

c) Kidney

d) Fatty acid synthesis

6. A fatty acid with 15 carbon atoms will undergo how many cycles of beta oxidation and produce how much acetyl CoA molecule?

a) 5 cycle and 5 acetyl CoA molecule

b) 6 cycle and 6 acetyl CoA molecule

c) 7 cycle and 7 acetyl CoA molecule

d) 8 cycle and 8 acetyl CoA molecule

7. Which out of the followings is the ketone body is maximum in diabetic ketoacidosis?

a) Acetone

b) Acetoacetate

c) Beta-hydroxy butyrate

d) Hydroxy Methyl glutarate

8. Respiratory distress syndrome in premature infants is due to inadequate secretion of which one of the following lipids:-

a) Dipalmitoylphosphatidyl lecithin

b) Spingomyelin

c) Cholesterol

d) Phosphatidyl inositol

9. Iodine number denotes

a) Degree of unsaturation

b) Saponification number

c) Acid number

d) Acetyl number

10. Which of the following enzymes is stimulated by glucagon?

a) Acetyl-CoA carboxylase

b) Glycogen phosphorylase

c) Glycogen synthase

d) HMG-CoA reductase

11. Vitamin C is required for the synthesis of

a) Bile acids from cholesterol

b) Bile salts from bile acids

c) Vitamin D from cholesterol

d) All of these

12. Which of the following can be oxidized by β-oxidation pathway?

a) Saturated fatty acids

b) Monosaturated fatty acids

c) Polyunsaturated fatty acids

d) All of these

13. A fatty acid which is not synthesized in the body and has to be supplied in the diet is

a) Palmitic acid

b) Lauric acid

c) Linolenic acid

d) Palmitoleic acid

14. The cholesterol molecule is

a) Benzene derivative

b) Quinoline derivative

c) Steroid

d) Straight chain acid

15. The enzymes of β-oxidation are found in

a) Mitochondria

b) Cytosol

c) Golgi apparatus

d) Nucleus

16. Gaucher's disease is due to deficiency of the enzyme:

a) Sphingomyelinase

b) Glucocerebrosidase

c) Galactocerbrosidase

d) β-Galactosidase

17. The number of double bonds in arachidonic acid is

a) 1

b) 2

c) 4

d) 6

18. Phospholipid acting as surfactant is

a) Cephalin

b) Phosphatidyl inositol

c) Lecithin

d) Phosphatidyl serine

19. Triglycerides are transported from liver to extrahepatic tissues by

a) Chylomicrons

b) VLDL

c) HDL

d) LDL

20. Carnitine is required for the transport of

a) Triglycerides out of liver

b) Triglycerides into mitochondria

c) Short chain fatty acids into mitochondria

d) Long chain fatty acids into mitochondria

21. B-Oxidation of odd-carbon fatty acid chain produces

a) Succinyl CoA

b) Propionyl CoA

c) Acetyl CoA

d) Malonyl CoA

22. Long-chain fatty acids are oxidized step-wise in one carbon units starting from the

a) Carboxyl end

b) Aliphatic end

c) Both (a) and (b)

d) None of these

23. All the following statements about ketone bodies are true except

a) Their synthesis increases in diabetes mellitus

b) They are synthesized in mitochondria

c) They can deplete the alkali reserve

d) They can be oxidized in the liver