| Заболевание
| Объект (доза)
| эффект
| ссылка
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| cardiovascular disease
| 45 volunteers\900 mL (6 cups) mineral water, green tea, or black tea/d. (4 wk)
| Consumption of 900 mL (6 cups) green or black tea/d did not affect serum lipid concentrations.
| Am J Clin Nutr. 1997 Nov;66(5):1125-32.van het Hof KH, de Boer HS, Wiseman SA, Lien N, Westrate JA, Tijburg LB.
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| atherosclerosis
| Human\black tea extract
| that black tea inhibited the proliferation of smooth muscle cells involved in the development and progression of atherosclerosis, and suppressed the production of oxidized low-density lipoprotein, a cause of lipid accumulation. That black tea has an antiatherosclerotic action.
| Biosci Biotechnol Biochem. 1998 Jan;62(1):44-8.Yokozawa T, Dong E, Nakagawa T, Kim DW, Hattori M, Nakagawa H.
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| cardiovascular disease
| Human\ orally ingested green tea extract (254 mg of total catechins/subject)
| The results suggested that drinking green tea contributes to prevent cardiovascular disease by increasing plasma antioxidant capacity in humans.
| J Agric Food Chem. 1999 Oct;47(10):3967-73.Nakagawa K, Ninomiya M, Okubo T, Aoi N, Juneja LR, Kim M, Yamanaka K, Miyazawa T.
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| ischemia/reperfusion brain injury
| Wistar rats for 3 weeks before induction of ischemia\ Green tea extract (0.5%) (orally)
| eventually result in protective effect on the ischemia/reperfusion-induced brain injury and behavior deficit.
| Brain Res Bull. 2000 Dec;53(6):743-9.Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Kim DB, Yun YP, Ryu JH, Lee BM, Kim PY.
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| coronary artery disease
| 66 patients with proven coronary artery disease\ consumption of 450 mL tea or900 mL tea (4 weeks)
| Short- and long-term black tea consumption reverses endothelial vasomotor dysfunction in patients with coronary artery disease. This finding may partly explain the association between tea intake and decreased cardiovascular disease events.
| Circulation. 2001;104:151 Stephen J. Duffy, MB, BS, PhD; John F. Keaney Jr, MD; Monika Holbrook, MA; Noyan Gokce, MD; Peter L. Swerdloff, BA; Balz Frei, PhD; Joseph A. Vita, MD
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| cardiovascular disease
| Human\black tea extract
| the protective effects of tea-derived flavonoids in inflammatory diseases.
| Cytokine. 2001 Mar 7;13(5):280-6. Crouvezier S, Powell B, Keir D, Yaqoob P.
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| atherosclerosis
| atherosclerosis-susceptible C57BL/6J, apoprotein (apo)E-deficient mice\ green tea extract (0.8 g/L). The tea extract consisted of the following (g/100 g): EGCg, 58.4; (-)-epigallocatechin (EGC), 11.7; (-)-epicatechin (EC), 6.6; (-)-gallocatechingallate (GCg), 1.6; (-)-epicatechin gallate (ECg), 0.5; and caffeine, 0.4. The estimated actual intake of tea catechin was 1.7 mg/(d. mouse).
| These results suggest that chronic ingestion of tea extract prevents the development of atherosclerosis without changing the plasma lipid level in apoE-deficient mice, probably through the potent antioxidative activity of the tea.
| J Nutr. 2001 Jan;131(1):27-32.Miura Y, Chiba T, Tomita I, Koizumi H, Miura S, Umegaki K, Hara Y, Ikeda M, Tomita T.
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| coronary artery disease
| 49 patients\ 450 mL of black tea or water consumed initially, followed by 900 mL of tea or water daily for 4 weeks
| chronic black tea consumption does not affect ex vivo platelet aggregation in patients with coronary artery disease.
| Arterioscler Thromb Vasc Biol 2001;21:1084-1089. Stephen J. Duffy; Joseph A. Vita; Monika Holbrook; Peter L. Swerdloff; John F. Keaney, Jr
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| ischemia/reperfusion brain injury
| animals \two doses (0.5 or 2%) of green tea extract for 3 weeks
| This study therefore suggests that green tea may be a useful agent for the prevention of cerebral ischemia damage
| Brain Res. 2001 Jan 5;888(1):11-18.Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Yun YP, Lee BM, Kim PY.
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| ischemia
| Rats \green tea extract (GTE). Free radicals in bile were trapped with the spin-trapping reagent alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone (4-POBN) and measured using electron spin resonance spectroscopy.
| these results demonstrate that GTE scavenges free radicals in the liver after ischemiareoxygenation, thus preventing formation of toxic cytokines.
| Am J Physiol Gastrointest Liver Physiol. 2002 Oct;283(4):G957-64.Zhong Z, Froh M, Connor HD, Li X, Conzelmann LO, Mason RP, Lemasters JJ, Thurman RG.
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| atopic dermatitis and chronic venous insufficiency
| Human\dietary supplements (tea tree oil)
| The use of complementary/alternative medicine treatments is not free of risk; direct and indirect risks associated with CAM must be considered.
| Am J Clin Dermatol. 2002;3(5):341-8.Ernst E, Pittler MH, Stevinson C.
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| cardiovascular disease
| human \green tea extract corresponding to a daily intake of 18.6 mg catechins/d
| The overall effect of the 10-week period without dietary fruits and vegetables was a decrease in oxidative damage to DNA, blood proteins, and plasma lipids, concomitantly with marked changes in antioxidative defence.
| Br J Nutr. 2002 Apr;87(4):343-55.Young JF, Dragstedt LO, Haraldsdottir J, Daneshvar B, Kal MA, Loft S, Nilsson L, Nielsen SE, Mayer B, Skibsted LH, Huynh-Ba T, Hermetter A, Sandstrom B.
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| cardiovascular disease
| Of the 1900 patients, 1019 consumed no tea (nondrinkers), 615 consumed <14 cups per week (moderate tea drinkers), and 266 consumed 14 or more cups per week (heavy tea drinkers).
| the effects of tea consumption on mortality after acute myocardial infarction are unknown. Self-reported tea consumption in the year before acute myocardial infarction is associated with lower mortality after infarction.
| Circulation 2002;105:2476-2481. Kenneth J. Mukamal, MD, MPH, MA; Malcolm Maclure, ScD; James E. Muller, MD; Jane B. Sherwood, RN; Murray A. Mittleman, MD, DrPH
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| cardiovascular disease
| 4807 men and women aged  55 y.\ tea drinkers with a daily intake >375 mL
| An increased intake of tea and flavonoids may contribute to the primary prevention of ischemic heart disease.
| Am. J. Clin. Nutr. 2002;75:880-886.Johanna M Geleijnse, Lenore J Launer, Deirdre AM van der Kuip, Albert Hofman and Jacqueline CM Witteman
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| cardiovascular disease
| In vitro and animal, men and women\ green or black tea extract
| Clinical trials employing putative intermediary indicators of disease, particularly biomarkers of oxidative stress status, suggest tea polyphenols could play a role in the pathogenesis of cancer and heart disease.
| J Am Coll Nutr 2002;21:1-13.Diane L. McKay, PhD and Jeffrey B. Blumberg, PhD, FACN
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| cardiovascular disease
| 13 subjects\ 1000 mL/d of green tea and black tea. 22 subjects\ 1250 mL/d of black tea (4 wk)
| not altered after regular ingestion of green tea (273 ± 48 pmol/mmol creatinine) or black tea (274 ± 39 pmol/mmol creatinine) in comparison with hot water (263 ± 47 pmol/mmol creatinine; Study 1), or by regular ingestion of black tea (334 ± 71 pmol/mmol creatinine) in comparison with hot water (355 ± 75 pmol/mmol creatinine; Study 2). These results do not support the suggestion that polyphenolic antioxidants derived from tea inhibit in vivo lipid peroxidation.
| J. Nutr. 2002;132:55-58.Jonathan M. Hodgson2, Kevin D. Croft, Trevor A. Mori, Valerie Burke, Lawrence J. Beilin and Ian B. Puddey
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| coronary heart disease
| 7 men and 8 women, consuming a controlled diet for 3 wk/treatment\ black tea consumption
| Tea consumption did not affect antioxidant status in this study.
| J. Nutr. 2003, 133:3298S-3302S,Michael J. Davies*, Joseph T. Judd*,2, David J. Baer*, Beverly A. Clevidence*, David R. Paul*, Alison J. Edwards*, Sheila A. Wiseman  , Richard A. Muesing** and Shirley C. Chen 
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| Cerebral ischemia
| in rodents, such as Mongolian gerbils and stroke-prone spontaneously hypertensive rats (SHRSP)\, green tea extract
| These results are important in light of an attenuation of the deleterious consequences of oxidative stress in ischemia and recirculation injury.
| Toxicology. 2003 Jul 15;189(1-2):55-61.Ikeda K, Negishi H, Yamori Y.
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| decreased cardiovascular
| 240 men and women 18 years or older\ a daily capsule containing theaflavin-enriched green tea extract (375 mg) (12 weeks).
| The theaflavin-enriched green tea extract we studied is an effective adjunct to a low-saturated-fat diet to reduce LDL-C in hypercholesterolemic adults and is well tolerated.
| Arch Intern Med. 2003;163:1448-1453. David J. Maron, MD; Guo Ping Lu, MD; Nai Sheng Cai, MD; Zong Gui Wu, MD; Yue Hua Li, MD; Hui Chen, MD; Jian Qiu Zhu, MD; Xue Juan Jin, MS; Bert C. Wouters, MA; Jian Zhao, PhD
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| cardiac hypertrophy, chronic renal failure
| Male Sprague-Dawley rats\ given green tea extract (0.1% and 0.25%)
| Administration of green tea extract at 0.25% resulted in attenuation of left ventricular hypertrophy, hypertension, and preserved cardiac Na-K-ATPase activity in rats subjected to remnant kidney surgery (all P < 0.01). Green tea extract appears to block the development of cardiac hypertrophy in experimental renal failure.
| Kidney Int. 2003 May;63(5):1785-90.Priyadarshi S, Valentine B, Han C, Fedorova OV, Bagrov AY, Liu J, Periyasamy SM, Kennedy D, Malhotra D, Xie Z, Shapiro JI.
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| cardiovascular disease
| 17 228 subjects (mean age, 59.5 years)\ of tea consumption (drinking <1, 1, 2, 3, and 4 cups/day)
| Tea intake, likely consumed as black tea, was not strongly associated with a reduced risk of CVD in this population
| Int. J. Epidemiol. 2003;32:527-533. Howard D Sesso1,2, Ralph S Paffenbarger, Jr1,3, Yuko Oguma1 and I-Min Lee1,2
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