Practical lesson 2

ANABOLISM OF LIPIDS. METABOLISM OF KETONE BODIES

Choose the correct answer:

1. Common precursors for synthesis of TG and PL are following except

A. glycerol 3 phosphate;

B. acyl CoA;

C. phosphatidic acid;

D. dioxyaceton phosphate;

E. citidyldiphosphorylglycerol.

2. For biosynthesis of palmitate needs following except

A. acetyl CoA;

B. NADPHH⁺;

C. CO₂ and ATP;

D. biotin;

E. vitamin C.

3. Enzymes participating for synthesis of palmitate are following except

A. isocitrate DH (in mitochondria);

B. citrate synthase;

C. malic enzyme;

D. acyl CoA carboxylase;

E. fatty acid synthase complex.

4. The reduction of NADP⁺ takes place in the following reactions and pathway. Choose one in correct answer

A.PPP;

B.HMP shunt;

C. “malic” reaction;

D. isocitrate DH reaction (cytosolic);

E. isocitrate DH reaction (mitochondria).

5.The key enzyme of fatty acid synthesis is…

A. citrate lyase;

B. acetyl CoA carboxylase;

C.3-ketoacyl synthase;

D.3-ketoacyl reductase;

E. β-hydroxy-β-metylglutaryl reductase.

6. Activator for fatty acid synthesis is…

A. adrenalin;

B. noradrenalin;

C. glucagon;

D. insulin;

E. cAMP

7. Acyl CoA carboxylase in…

A. mitochondria;

B. cytosol;

C. endoplasmic reticulum;

D. liposome;

E. microsome.

8. Fatty acid synthase complex in….

A. mitochondria;

B. cytosol;

C. endoplasmic reticulum;

D. liposome;

E. microsome.

9. Which one of the following statement about fatty acid synthase is in correct.

A. in human body synthase exists as a dimer;

B. synthase complex contains of 7 enzymes;

C. as source of reduced equivalent NADPHH⁺ is used;

D. location in cytosol;

E. needs for biotin

10. Shuttle system participating in the synthesis of fatty acid is…

A. malate-aspartate;

B. glycerophosphate;

C. malate.

D. citrate;

E. carnitine

PRACTICAL LESSON 3