One of the consequences of the patient's poisoning is a significant decrease of the various blood cell counts. What are the possible mechanisms of this effect?

With regard to the results of the special blood tests what mechanisms of the cell damage can you propose? Which of them caused damage to the membrane of the formal particles? Substantiate your position?

What are the origin and consequences of acidosis in this case?

Why did the signs of intoxication develop in the patient not immediately but 2 days later after the incident?

Case 3

For experimental modeling of hemolytic anemia mice were treated by phenylhydrazine, which stimulated free-radical reactions. After Half an hour decrease in red blood cells count, the presence of free Hb and methemoglobin in blood were revealed

Questions
1.Specify the stage of acute cell damage
2.Specify the sequence of pathological changes during the cell damage
3.Explain the appearance of free hemoglobin in the blood
4. Explain the appearance of methemoglobin in the blood

Case 4

Is it possible to set the type of damaged cells on the basis of the following indicators?

Plasma Potassium concentration is - 5.5 mmol / l (normal 3.5-5.0 mmol / l), activity of AST and ALT increased, myoglobin is detected in the urine.
Questions:
1. Specify the mechanisms of cellular membrane damage
2. Specify the consequences of cellular membrane damage
3. Markers of which damaged cells are blood ALT, AST, myoglobin
4. Give examples of markers of erythrocyte, cardiomyocyte cytolysis

Case 5

A Laboratory doctor revealed pronounced hemolysis of erythrocytes. Blood smear revealed spherical erythrocytes. When asking for the situation he found that during preparation of a blood sample hypotonic solution of sodium chloride was used:

Questions:
1. Specify the mechanisms of cellular membrane damage
2. Explain the pathogenesis of erythrocyte destruction in the blood sample
3. Why did red blood cells have spherical shape?
4. Describe adaptive mechanisms operating during cell injury

Hand-outs: cases, lecture, multimedia presentation

7.7.4. THE LIST OF LITERATURE:

The basic

Litvitsky P.F., Pirozhkov S.V., Tezikov E.B. Concise lectures and tests on pathophysiology E-tekstbook. – ГЭОТАР-Медиа, 2007
Lectures, handouts.
Pathologic basis of disease. Cellular adaptations. Cell injury and cell death. V.Kumar, A.K. Abbas, S.N. Fausto, 8th edition, 2010, P. 3 - 46
Basic Pathology. Vinay Kumar, Ramsi S. Cotran, Stanley L. Robbins. 9^th edition, 2013.- P 3 - 24.

Additional