Why does chronic gastric atrophy promote the development of a gastric tumor?

Can we suspect the insufficiency of the antineoplastic mechanisms in this case? If we can, describe these mechanisms.

What are the possible causes and mechanisms of fever and anemia in this patient?

What are the possible causes of cachexia in this patient?

Case 4

A 40-year-old patient B. 1.5 years before had participated in the liquidation of the nuclear power station accident. He visited his physician with complaints of considerable weakness, dizziness, persistent coughing with minor secretions. He told the physician that he had been a heavy smoker for 20 years, but 2 years before had given up smoking. During the last 6 months he repeatedly suffered infectious diseases, such as quinsy, bronchitis, pneumonia. During bronchoscopy a tumor of the main right bronchus was found. Histology of the tumor showed the presence of malignant cells.

Questions:

What factor was the most likely cause of bronchial cancer in this patient? Substantiate your answer.

What factors could potentiate the effect of carcinogens in this patient? What are their possible mechanisms of action?

3. What antineoplastic mechanisms should have become activated in this patient:

- under the effect of the carcinogens?

- in the course of neoplastic transformation of the bronchial epithelial cell?

- during the formation of the primary tumor nodule?

Why did the antineoplastic mechanisms fail in this case?

Hand-outs: cases, lecture, multimedia presentation

7.7.14. THE LIST OF LITERATURE:

The basic

Litvitsky P.F., Pirozhkov S.V., Tezikov E.B. Concise lectures and tests on pathophysiology E-tekstbook. – ГЭОТАР-Медиа, 2007