The approximate timing of class

Questions for the theme

Definition and significance of inflammation. Causes of inflammation.

Primary and secondary alteration in the focus of acute inflammation: causes, mechanisms of development, manifestation. Physico-chemical changes in the focus of inflammation. Metabolic disorders in the focus of inflammation

Sources, nature and effects of inflammatory mediators

Sequence and mechanisms of vascular changes in acute inflammation.

Exudation. Definitions of an exudate and transudate. Mechanisms of vascular leakage in acute inflammation.

Stages of extravasation. Mechanisms of margination, rolling, firm adhesion and transmigration. Inflammatory mediators that influence on these processes.

Chemotaxis: definition, exogenous and endogenous chemoattractants, regulatory (receptor) mechanisms of chemotaxis.

Phagocytosis: stages, mechanisms of bacterial killing (oxygen free radicals, products of secondary and lysosomal granules). Frustrated phagocytosis. Defects in leukocyte function. Defects in leukocyte adhesion and intracellular digestion

9. Proliferation, notion, pathogenesis

Local and systemic signs of inflammation

11. Chronic inflammation, etiology, pathogenesis, differences from acute inflammation

The general principles of prophylaxis and therapy of inflammatory processes. C

Methods of teaching

Discussion the major issues under the supervision of a teacher, discussion of videos, Konheim experiment

6.6.10. THE LIST OF LITERATURE:

The basic

10. Litvitsky P.F., Pirozhkov S.V., Tezikov E.B. Concise lectures and tests on pathophysiology E-tekstbook. – ГЭОТАР-Медиа, 2007

11. Pathologic basis of disease. Acute and chronic inflammation.V. Kumar, A.K. Abbas, S.N. Fausto, 8th edition, 2010.- P. 47-87

12. Basic Pathology. Acute and chronic inflammation. Vinay Kumar, Ramsi S. Cotran, Stanley L. Robbins. 9^th edition, 2013.

Additional

13. Textbook of pathology. Harsh Mohan. 4rd edition, Delhi, 2004.-P. 133-156.

Methods of control

Oral questioning, conclusions on experiment, testing

The approximate timing of class

№	Steps of the class	Time (min)
	Organizational part. Roll Call, reading the goals and objectives of the class, distribution of demonstration material
	Discussion the questions
	Break
	Watching videos and their discussion
	Experimental work
	Test
	Summarizing the classroom work, assessment of competencies

Practical work

The task № 1.

Study the blood-flow disorders and stages of leukocytes emigration at inflammation of frog’s mesentery (Konheim experiment)

Technique: Make the preparation of frog’s mesentery. Under a microscope observe blood circulation in micro vessels. Pay attention to vascular lumen, amount of capillaries, and speed of blood-flow. Mark leukocytes margination and leukocyte emigration. Explain the results.