Знаков)

in Calan) Galactorrhea/hyperprolactinemia has been reported during open trials/postmarketing experience.[Ref]

Due to verapamil-induced hyperprolactinemia, rare cases of galactorrhea have been reported in both sexes.[Ref]

Renal

Renal side effects have included rare cases of oliguria and worsened renal function in patients with preexisting chronic renal failure.[Ref]

Rare cases of hypertensive patients with chronic renal failure who developed acute oliguric renal failure after receiving verapamil have been reported. These patients also developed symptomatic hypotension associated with slow cardiac arrhythmias.[Ref]

Genitourinary

Genitourinary side effects have included rare cases of sexual impotence and loss of libido among males. Gynecomastia, galactorrhea/hyperprolactinemia, impotence, increased urination, and spotty menstruation have been reported during open trials/postmarketing experience.[Ref]

After the onset of impotence, one patient elected to discontinue verapamil. His impotence resolved upon drug discontinuation, and recurred upon rechallenge.[Ref]

Musculoskeletal

Musculoskeletal side effects have included myalgia (up to 1.1%) and bizarre perceptual symptoms most closely described as cold extremities. Muscle fatigue has been reported with intravenous verapamil (the active ingredient contained in Calan) Arthralgia (with rash) and muscle cramps have been reported during open trials/postmarketing experience.[Ref]

Three case reports have been found by one practitioner. In each case, unusual symptoms of cold extremities and paresthesias without objective evidence of a neuromuscular or cardiac etiology were described. The symptoms resolved upon discontinuation and, in each case, recurred upon drug rechallenge.[Ref]

Psychiatric

Psychiatric side effects have included rare cases of depression. Emotional depression has been reported with intravenous verapamil (the active ingredient contained in Calan) Psychotic symptoms have been reported during open trials/postmarketing experience.[Ref]

Hematologic

Hematologic side effects have included ecchymosis or bruising during open trials/postmarketing experience.[Ref]

Hypersensitivity